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2023

 

UNVEILING THE INFLUENCE OF TUMOR MICROENVIRONMENT AND SPATIAL HETEROGENEITY ON TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA USING AN ADVANCED HUMAN IN VITRO MODEL OF THE BLOOD-BRAIN BARRIER AND GLIOBLASTOMA

Maxine S.Y. Lam, Joey Aw, Damien Tan, Ragavi Vijayakumar, HY Grace Lim, Swathi Yada, QY Pang, Nicholas Barker, Carol Tang, BT Ang, Radoslaw M. Sobota, Andrea Pavesi 

Small (2023). https://doi.org/10.1002/smll.202302280

CHARACTERIZATION OF 3D HETEROCELLULAR SPHEROIDS OF PANCREATIC DUCTAL ADENOCARCINOMA FOR THE STUDY OF CELL INTERACTIONS IN THE TUMOR IMMUNE MICROENVIRONMENT

Giulio Giustarini, Germaine Teng, Andrea Pavesi, Giulia Adriani

Frontiers in Oncology, 13 (2023). https://doi.org/10.3389/fonc.2023.1156769

LYTIC EFFICIENCY OF IMMUNOSUPPRESSIVE DRUGS RESISTANT ARMORED T CELLS AGAINST CIRCULATING HBV-RELATED HCC IN WHOLE BLOOD

M. Lin, Sebastian Chakrit Bhakdi, Damien Tan, Joycelyn J.X. Lee, David W.M. Tai, Andrea Pavesi, Lu-En Wai, Tina Wang, Anthony T. Tan, Antonio Bertoletti

Immunotherapy Advances, Vol 3 Issue 1 (2023). https://doi.org/10.1093/immadv/ltad015

G9A/GLP INHIBITION DURING EX VIVO LYMPHOCYTE EXPANSION INCREASES IN VIVO CYTOTOXICITY OF ENGINEERED T CELLS AGAINST HEPTAOCELLULAR CARCINOMA 

Maxine S. Y. Lam, Jose Antonio Reales-Calderon, Jin Rong Ow, Joey J. Y. Aw, Damien Tan, Ragavi Vijayakumar, Erica Ceccarello, Tommaso Tabaglio, Yan Ting Lim, Wang Loo Chien, Fritz Lai, Anthony Tan Tanoto, Qingfeng Chen, Radoslaw M. Sobota, Giulia Adriani, Antonio Bertoletti, Ernesto Guccione,  Andrea Pavesi

Nat Commun 14, 563 (2023). https://doi.org/10.1038/s41467-023-36160-5

2022

 

A HUMAN NEUROVASCULAR UNIT ON-A-CHIP

Sharon W.L. Lee, Renato Rogosic, Claudia Venturi, Manuela Teresa Raimondi, Andrea PavesiGiulia Adriani.

Organ-on-a-Chip, 107-119; doi: https://link.springer.com/protocol/10.1007/978-1-0716-1693-2_7

2021

 

A 3D PANCREATIC TUMOR MODEL TO STUDY T CELL INFILTRATION

Hilaria Mollica, Yi Juan Teo, Alrina Shin Min Tan, Damien Tan, Paolo Decuzzi, Andrea PavesiGiulia Adriani.

Biomater. Sci., 2021 Oct 27, 9, 7420-7431; doi: https://doi.org/10.1039/D1BM00210D

IN-VITRO 3D LIVER TUMOR MICROENVIRONMENT MODELS FOR IMMUNE CELL THERAPY OPTIMIZATION

Maxine Lam, Jose Antonio Reales Calderon, Jin Rong Ow, Giulia Adriani, Andrea Pavesi.

APL Bioengineering 5 (4), 041502; doi: https://doi.org/10.1063/5.0057773

HUMAN MAIT CELLS ENDOWED WITH HBV SPECIFICITY ARE CYTOTOXIC AND MIGRATE TOWARDS HBV-HCC WHILE RETAINING ANTIMICROBIAL FUNCTIONS

Katie Healy, Andrea Pavesi, Tiphaine Parrot, Michał J. Sobkowiak, Susanne E. Reinsbach, Haleh Davanian, Anthony T. Tan, Soo Aleman, Johan K. Sandberg, Antonio Bertoletti, Margaret Sällberg Chen.

JHEP Reports. 2021 Jun 11; doi: https://doi.org/10.1016/j.jhepr.2021.100318

NANOPARTICLE-BASED THERAPIES FOR TURNING COLD TUMORS HOT: HOW TO TREAT AN IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

Giulio Giustarini, Andrea Pavesi, Giulia Adriani.

Front. Bioeng. Biotechnol. 2021 Jun 2; 9:458. doi: https://doi.org/10.3389/fbioe.2021.689245

SPLICE-SWITCHING ANTISENSE OLIGONUCLEOTIDES AS A TARGETED INTRINSIC ENGINEERING TOOL FOR GENERATING ARMORED REDIRECTED T CELLS

Erica Ceccarello, Tommaso Tabaglio, Sarene Koh, Vincent Oei, Winnie Teo, Owen Julianto Jonathan, Andrea Pavesi, Qingfeng Chen, Antonio Bertoletti, Keng Boon Wee, Ernesto Guccione.

nucleic acid therapeutics. 2021 Feb 9; https://doi.org/10.1089/nat.2020.0905

SHAPING IN VITRO SOLID TUMOR MICROENVIRONMENT FOR CELL THERAPY OPTIMISATION

Andrea Pavesi.

Cancer Science. 2021 Feb 1; 112, 175-175

2020

 

IMMUNOSUPPRESIVE DRUG-RESISTANT ARMORED TCR T CELLS FOR IMMUNE-THERAPY OF HCC IN LIVER TRANSPLANT PATIENTS

Morteza Hafezi, Meiyin Lin, Adeline Chia, Alicia Chua, Zi Zong Ho, Royce Fam, Damien Tan, Joey Aw, Andrea Pavesi, Thinesh Lee Krishnamoorthy, Wan Cheng Chow, Wenjie Chen, Qi Zhang, Lu‐En Wai, Sarene Koh, Anthony T. Tan, Antonio Bertoletti

Hepatology. 2020 Nov 29; doi: https://doi.org/10.1002/hep.31662

CRISPR MEDIATED BASE CONVERSION ALLOWS DISCRIMINATORY DEPLETION OF ENDOGENOUS T CELL RECEPTORS FOR ENHANCED SYNTHETIC IMMUNITY

Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K Maini, Antonio Bertoletti, Waseem Qasim.

Mol Ther. 2020 Sep 11; doi: https://doi.org/10.1016/j.omtm.2020.09.002

METTL6 IS A TRNA M3C METHYLTRANSFERASE THAT REGULATES PLURIPOTENCY AND TUMOR CELL GROWTH

Valentina V Ignatova, Steffen Kaiser, Jessica Sook Yuin Ho, Xinyang Bing, Paul Stolz, Ying Xim Tan, Chee Leng Lee, Florence Pik Hoon Gay, Palma Rico Lastres, Raffaele Gerlini, Birgit Rathkolb, Antonio Aguilar-Pimentel, Adrián Sanz-Moreno, Tanja Klein-Rodewald, Julia Calzada-Wack, Emil Ibragimov, Magdalena Valenta, Saulius Lukauskas, Andrea Pavesi, Susan Marschall, Stefanie Leuchtenberger, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe De Angelis, Sebastian Bultmann, Oliver J Rando, Ernesto Guccione, Stefanie M Kellner, Robert Schneider.

Science Advances. 2020 Aug 26; Vol. 6, no. 35, eaaz4551. doi: https://www.science.org/doi/10.1126/sciadv.aaz4551

T CELL RECEPTOR-ENGINEERED MUCOSAL-ASSOCIATED INVARIANT T CELLS WITH ANTIVIRAL CYTOTOXIC POTENTIAL AGAINST HEPATITIS VIRUS REPLICATING HEPATOMA CELLS

Katie Healy, Andrea Pavesi, Tiphaine Parrot, Haleh Davanian, Anthony Tan, Johan K Sandberg, Antonio Bertoletti, Margaret Sällberg Chen.

Journal of Hepatology. 2020 Aug 1; 73, S83-S84

RECOMBINANT T CELL RECEPTOR IMMUNITY AGAINST HEPATITIS B SURFACE ANTIGEN FOLLOWING DISRUPTIVE BASE EDITING OF ENDOGENOUS T CELL RECEPTOR

Soragia-Athina Gkazi, Roland Preece, Andrea Pavesi, Kerstin Stegmann, Christos Georgiadis, Damien Tan, Joey Ying Aw, Mala Maini, Antonio Bertoletti, Waseem Qasim.

Mol Ther. 2020 Apr 28; (4), 340-340

2019

PHTHALIMIDE DERIVATIVE SHOWS ANTI-ANGIOGENIC ACTIVITY IN A 3D MICROFLUIDIC MODEL AND NO TERATOGENICITY IN ZEBRAFISH EMBRYOS

Mercurio A, Sharples L, Corbo F, Franchini C, Vacca A, Catalano A, Carocci A, Kamm RD, Pavesi A, Adriani G.

Front Pharmacol. 2019 Apr 17; 10:349. doi: https://doi.org/10.3389/fphar.2019.00349. eCollection 2019.

2018

A COMBINED MICROFLUIDIC-TRANSCRIPTOMIC APPROACH TO CHARACTERIZE THE EXTRAVASATION POTENTIAL OF CANCER CELLS

Bersini S, Miermont A, Pavesi A, Kamm RD, Thiery JP, Moretti M, Adriani G.

Oncotarget. 2018 Nov 16; 9(90):36110-36125. doi: https://doi.org/10.18632/oncotarget.26306

 

MOLECULAR RECALIBRATION OF PD-1+ ANTIGEN-SPECIFIC T CELLS FROM BLOOD AND LIVER

Otano I, Escors D, Schurich A, Singh H, Robertson F, Davidson BR, Fusai G, Vargas FA, Tan ZMD, Aw JYJ, Hansi N, Kennedy PTF, Xue SA, Stauss HJ, Bertoletti A, Pavesi A, Maini MK.

Mol Ther. 2018 Nov 7; 26(11):2553-2566. doi: https://doi.org/10.1016/j.ymthe.2018.08.013

 

MBNL1 ALTERNATIVE SPLICING ISOFORMS PLAY OPPOSING ROLES IN CANCER

Tabaglio T, Low DH, Teo WKL, Goy PA, Cywoniuk P, Wollmann H, Ho J, Tan D, Aw J, Pavesi A, Sobczak K, Wee DKB, Guccione E.

Life Sci. Alliance. 2018 Sep 7. doi: https://doi.org/10.26508/lsa.201800157

 

NONLYTIC LYMPHOCYTES ENGINEERED TO EXPRESS VIRUS-SPECIFIC T-CELL RECEPTORS LIMIT HBV INFECTION BY ACTIVATING APOBEC3

Koh S, Kah J, Tham CYL, Yang N, Ceccarello E, Chia A, Chen M, Khakpoor A, Pavesi A, Tan AT, Dandri M, Bertoletti A.

Gastroenterology. 2018 Jul; 155(1):180-193.e6. doi: https://doi.org/10.1053/j.gastro.2018.03.027

 

STUDYING TCR T CELL ANTI-TUMOR ACTIVITY IN A MICROFLUIDIC INTRAHEPATIC TUMOR MODEL

Adriani G, Pavesi A, Kamm RD.

Methods Cell Biol. 2018; 146:199-214. doi: https://doi.org/10.1016/bs.mcb.2018.05.009

 

CHARACTERIZING THE ROLE OF MONOCYTES IN T CELL CANCER IMMUNOTHERAPY USING A 3D MICROFLUIDIC MODEL

Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC.

Front Immunol. 2018 Mar 6; 9:416. doi: https://doi.org/10.3389/fimmu.2018.00416

2017

 

A 3D MICROFLUIDIC MODEL FOR PRECLINICAL EVALUATION OF TCR-ENGINEERED T CELLS AGAINST SOLID TUMORS

Pavesi A, Tan AT, Koh S, Chia A, Colombo M, Antonecchia E, Miccolis C, Ceccarello E, Adriani G, Raimondi MT, Kamm RD, Bertoletti A.

JCI Insight. 2017 Jun 15; 2(12). pii: 89762. doi: https://doi.org/10.1172/jci.insight.89762. eCollection 2017 Jun 15.

 

 

HUMAN CARDIAC FIBROBLASTS ADAPTIVE RESPONSES TO CONTROLLED COMBINED MECHANICAL STRAIN AND OXYGEN CHANGES IN VITRO

Ugolini GS, Pavesi A, Rasponi M, Fiore GB, Kamm R, Soncini M.

Elife. 2017 Mar 18; 6. pii: e22847. doi: https://doi.org/10.7554/eLife.22847

 

A 3D NEUROVASCULAR MICROFLUIDIC MODEL CONSISTING OF NEURONS, ASTROCYTES AND CEREBRAL ENDOTHELIAL CELLS AS A BLOOD-BRAIN BARRIER

Adriani G, Ma D, Pavesi A, Kamm RD, Goh EL.

Lab Chip. 2017 Jan 31; 17(3):448-459. doi: https://doi.org/10.1039/c6lc00638h

 

2016

 

MICROFLUIDIC MODELS FOR ADOPTIVE CELL-MEDIATED CANCER IMMUNOTHERAPIES

Adriani G, Pavesi A, Tan AT, Bertoletti A, Thiery JP, Kamm RD.

Drug Discov Today. 2016 Sep; 21(9):1472-1478. doi: https://doi.org/10.1016/j.drudis.2016.05.006

 

ADVANCES IN MICROFLUIDICS IN COMBATING INFECTIOUS DISEASES

Tay A, Pavesi A, Yazdi SR, Lim CT, Warkiani ME.

Biotechnol Adv. 2016 Jul-Aug; 34(4):404-421. doi: https://doi.org/10.1016/j.biotechadv.2016.02.002

 

ENGINEERING A 3D MICROFLUIDIC CULTURE PLATFORM FOR TUMOR-TREATING FIELD APPLICATION

Pavesi A, Adriani G, Tay A, Warkiani ME, Yeap WH, Wong SC, Kamm RD.

Sci Rep. 2016 May 24; 6:26584. doi: https://doi.org/10.1038/srep26584

PUBLISHED WORK

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