2025
MICROPHYSIOLOGICAL SYSTEMS IN CANCER RESEARCH: ADVANCING IMMUNOTHERAPY THROUGH TUMOR MICROENVIRONMENT-INTEGRATED ORGAN-ON-CHIP MODELS
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi
Advanced Therapeutics (2025), e00098. https://doi.org/10.1002/adtp.202500098
POOLED SCREENING FOR CAR FUNCTION IDENTIFIES NOVEL IL-13Rα2-TARGETED CARS FOR TREATMENT OF GLIOBLASTOMA
Giulia Adriani Gordon, K. S., Perez, C. R., Garmilla, A., Lam, M. S. Y., Aw, J. J. Y., Datta, A., Lauffenburger, D. A., Pavesi, A., & Birnbaum, M. E.
Journal for immunotherapy of cancer (2025), 13(2), e009574. https://doi.org/10.1136/jitc-2024-009574
IN VITRO INTEGRATION OF A FUNCTIONAL VASCULATURE TO MODEL ENDOTHELIAL REGULATION OF CHEMOTHERAPY AND T-CELL IMMUNOTHERAPY IN LIVER CANCER
Jyothsna Vasudevan, Ragavi Vijayakumar, Jose Antonio Reales-Calderon, Maxine S.Y. Lam, Jin Rong Ow, Joey Aw, Damien Tan, Anthony Tanoto Tan, Antonio Bertoletti, Giulia Adriani, Andrea Pavesi
Small Biomaterials (2025). https://doi.org/10.1016/j.biomaterials.2025.123175
2024
THE ORGANIX MICROFLUIDIC SYSTEM TO RECREATE THE COMPLEX TUMOUR MICROENVIRONMENT
Giulia Adriani & Andrea Pavesi
Nature Review Immunology 24, 307 (2024). https://doi.org/10.1038/s41577-024-01011-x
2023
UNVEILING THE INFLUENCE OF TUMOR MICROENVIRONMENT AND SPATIAL HETEROGENEITY ON TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA USING AN ADVANCED HUMAN IN VITRO MODEL OF THE BLOOD-BRAIN BARRIER AND GLIOBLASTOMA
Maxine S.Y. Lam, Joey Aw, Damien Tan, Ragavi Vijayakumar, HY Grace Lim, Swathi Yada, QY Pang, Nicholas Barker, Carol Tang, BT Ang, Radoslaw M. Sobota, Andrea Pavesi
Small (2023). https://doi.org/10.1002/smll.202302280
CHARACTERIZATION OF 3D HETEROCELLULAR SPHEROIDS OF PANCREATIC DUCTAL ADENOCARCINOMA FOR THE STUDY OF CELL INTERACTIONS IN THE TUMOR IMMUNE MICROENVIRONMENT
Giulio Giustarini, Germaine Teng, Andrea Pavesi, Giulia Adriani
Frontiers in Oncology, 13 (2023). https://doi.org/10.3389/fonc.2023.1156769
LYTIC EFFICIENCY OF IMMUNOSUPPRESSIVE DRUGS RESISTANT ARMORED T CELLS AGAINST CIRCULATING HBV-RELATED HCC IN WHOLE BLOOD
M. Lin, Sebastian Chakrit Bhakdi, Damien Tan, Joycelyn J.X. Lee, David W.M. Tai, Andrea Pavesi, Lu-En Wai, Tina Wang, Anthony T. Tan, Antonio Bertoletti
Immunotherapy Advances, Vol 3 Issue 1 (2023). https://doi.org/10.1093/immadv/ltad015
G9A/GLP INHIBITION DURING EX VIVO LYMPHOCYTE EXPANSION INCREASES IN VIVO CYTOTOXICITY OF ENGINEERED T CELLS AGAINST HEPTAOCELLULAR CARCINOMA
Maxine S. Y. Lam, Jose Antonio Reales-Calderon, Jin Rong Ow, Joey J. Y. Aw, Damien Tan, Ragavi Vijayakumar, Erica Ceccarello, Tommaso Tabaglio, Yan Ting Lim, Wang Loo Chien, Fritz Lai, Anthony Tan Tanoto, Qingfeng Chen, Radoslaw M. Sobota, Giulia Adriani, Antonio Bertoletti, Ernesto Guccione, Andrea Pavesi
Nat Commun 14, 563 (2023). https://doi.org/10.1038/s41467-023-36160-5
2022
A HUMAN NEUROVASCULAR UNIT ON-A-CHIP
Sharon W.L. Lee, Renato Rogosic, Claudia Venturi, Manuela Teresa Raimondi, Andrea Pavesi, Giulia Adriani.
Organ-on-a-Chip, 107-119; doi: https://link.springer.com/protocol/10.1007/978-1-0716-1693-2_7
2021
A 3D PANCREATIC TUMOR MODEL TO STUDY T CELL INFILTRATION
Hilaria Mollica, Yi Juan Teo, Alrina Shin Min Tan, Damien Tan, Paolo Decuzzi, Andrea Pavesi, Giulia Adriani.
Biomater. Sci., 2021 Oct 27, 9, 7420-7431; doi: https://doi.org/10.1039/D1BM00210D
IN-VITRO 3D LIVER TUMOR MICROENVIRONMENT MODELS FOR IMMUNE CELL THERAPY OPTIMIZATION
Maxine Lam, Jose Antonio Reales Calderon, Jin Rong Ow, Giulia Adriani, Andrea Pavesi.
APL Bioengineering 5 (4), 041502; doi: https://doi.org/10.1063/5.0057773
HUMAN MAIT CELLS ENDOWED WITH HBV SPECIFICITY ARE CYTOTOXIC AND MIGRATE TOWARDS HBV-HCC WHILE RETAINING ANTIMICROBIAL FUNCTIONS
Katie Healy, Andrea Pavesi, Tiphaine Parrot, Michał J. Sobkowiak, Susanne E. Reinsbach, Haleh Davanian, Anthony T. Tan, Soo Aleman, Johan K. Sandberg, Antonio Bertoletti, Margaret Sällberg Chen.
JHEP Reports. 2021 Jun 11; doi: https://doi.org/10.1016/j.jhepr.2021.100318
NANOPARTICLE-BASED THERAPIES FOR TURNING COLD TUMORS HOT: HOW TO TREAT AN IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT
Giulio Giustarini, Andrea Pavesi, Giulia Adriani.
Front. Bioeng. Biotechnol. 2021 Jun 2; 9:458. doi: https://doi.org/10.3389/fbioe.2021.689245
SPLICE-SWITCHING ANTISENSE OLIGONUCLEOTIDES AS A TARGETED INTRINSIC ENGINEERING TOOL FOR GENERATING ARMORED REDIRECTED T CELLS
Erica Ceccarello, Tommaso Tabaglio, Sarene Koh, Vincent Oei, Winnie Teo, Owen Julianto Jonathan, Andrea Pavesi, Qingfeng Chen, Antonio Bertoletti, Keng Boon Wee, Ernesto Guccione.
nucleic acid therapeutics. 2021 Feb 9; https://doi.org/10.1089/nat.2020.0905
SHAPING IN VITRO SOLID TUMOR MICROENVIRONMENT FOR CELL THERAPY OPTIMISATION
Andrea Pavesi.
Cancer Science. 2021 Feb 1; 112, 175-175
2020
IMMUNOSUPPRESIVE DRUG-RESISTANT ARMORED TCR T CELLS FOR IMMUNE-THERAPY OF HCC IN LIVER TRANSPLANT PATIENTS
Morteza Hafezi, Meiyin Lin, Adeline Chia, Alicia Chua, Zi Zong Ho, Royce Fam, Damien Tan, Joey Aw, Andrea Pavesi, Thinesh Lee Krishnamoorthy, Wan Cheng Chow, Wenjie Chen, Qi Zhang, Lu‐En Wai, Sarene Koh, Anthony T. Tan, Antonio Bertoletti
Hepatology. 2020 Nov 29; doi: https://doi.org/10.1002/hep.31662
CRISPR MEDIATED BASE CONVERSION ALLOWS DISCRIMINATORY DEPLETION OF ENDOGENOUS T CELL RECEPTORS FOR ENHANCED SYNTHETIC IMMUNITY
Roland Preece, Andrea Pavesi, Soragia Athina Gkazi, Kerstin A Stegmann, Christos Georgiadis, Zhi Ming Tan, Jia Ying Joey Aw, Mala K Maini, Antonio Bertoletti, Waseem Qasim.
Mol Ther. 2020 Sep 11; doi: https://doi.org/10.1016/j.omtm.2020.09.002
METTL6 IS A TRNA M3C METHYLTRANSFERASE THAT REGULATES PLURIPOTENCY AND TUMOR CELL GROWTH
Valentina V Ignatova, Steffen Kaiser, Jessica Sook Yuin Ho, Xinyang Bing, Paul Stolz, Ying Xim Tan, Chee Leng Lee, Florence Pik Hoon Gay, Palma Rico Lastres, Raffaele Gerlini, Birgit Rathkolb, Antonio Aguilar-Pimentel, Adrián Sanz-Moreno, Tanja Klein-Rodewald, Julia Calzada-Wack, Emil Ibragimov, Magdalena Valenta, Saulius Lukauskas, Andrea Pavesi, Susan Marschall, Stefanie Leuchtenberger, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe De Angelis, Sebastian Bultmann, Oliver J Rando, Ernesto Guccione, Stefanie M Kellner, Robert Schneider.
Science Advances. 2020 Aug 26; Vol. 6, no. 35, eaaz4551. doi: https://www.science.org/doi/10.1126/sciadv.aaz4551
T CELL RECEPTOR-ENGINEERED MUCOSAL-ASSOCIATED INVARIANT T CELLS WITH ANTIVIRAL CYTOTOXIC POTENTIAL AGAINST HEPATITIS VIRUS REPLICATING HEPATOMA CELLS
Katie Healy, Andrea Pavesi, Tiphaine Parrot, Haleh Davanian, Anthony Tan, Johan K Sandberg, Antonio Bertoletti, Margaret Sällberg Chen.
Journal of Hepatology. 2020 Aug 1; 73, S83-S84
RECOMBINANT T CELL RECEPTOR IMMUNITY AGAINST HEPATITIS B SURFACE ANTIGEN FOLLOWING DISRUPTIVE BASE EDITING OF ENDOGENOUS T CELL RECEPTOR
Soragia-Athina Gkazi, Roland Preece, Andrea Pavesi, Kerstin Stegmann, Christos Georgiadis, Damien Tan, Joey Ying Aw, Mala Maini, Antonio Bertoletti, Waseem Qasim.
Mol Ther. 2020 Apr 28; (4), 340-340
2019
PHTHALIMIDE DERIVATIVE SHOWS ANTI-ANGIOGENIC ACTIVITY IN A 3D MICROFLUIDIC MODEL AND NO TERATOGENICITY IN ZEBRAFISH EMBRYOS
Mercurio A, Sharples L, Corbo F, Franchini C, Vacca A, Catalano A, Carocci A, Kamm RD, Pavesi A, Adriani G.
Front Pharmacol. 2019 Apr 17; 10:349. doi: https://doi.org/10.3389/fphar.2019.00349. eCollection 2019.
2018
A COMBINED MICROFLUIDIC-TRANSCRIPTOMIC APPROACH TO CHARACTERIZE THE EXTRAVASATION POTENTIAL OF CANCER CELLS
Bersini S, Miermont A, Pavesi A, Kamm RD, Thiery JP, Moretti M, Adriani G.
Oncotarget. 2018 Nov 16; 9(90):36110-36125. doi: https://doi.org/10.18632/oncotarget.26306
MOLECULAR RECALIBRATION OF PD-1+ ANTIGEN-SPECIFIC T CELLS FROM BLOOD AND LIVER
Otano I, Escors D, Schurich A, Singh H, Robertson F, Davidson BR, Fusai G, Vargas FA, Tan ZMD, Aw JYJ, Hansi N, Kennedy PTF, Xue SA, Stauss HJ, Bertoletti A, Pavesi A, Maini MK.
Mol Ther. 2018 Nov 7; 26(11):2553-2566. doi: https://doi.org/10.1016/j.ymthe.2018.08.013
MBNL1 ALTERNATIVE SPLICING ISOFORMS PLAY OPPOSING ROLES IN CANCER
Tabaglio T, Low DH, Teo WKL, Goy PA, Cywoniuk P, Wollmann H, Ho J, Tan D, Aw J, Pavesi A, Sobczak K, Wee DKB, Guccione E.
Life Sci. Alliance. 2018 Sep 7. doi: https://doi.org/10.26508/lsa.201800157
NONLYTIC LYMPHOCYTES ENGINEERED TO EXPRESS VIRUS-SPECIFIC T-CELL RECEPTORS LIMIT HBV INFECTION BY ACTIVATING APOBEC3
Koh S, Kah J, Tham CYL, Yang N, Ceccarello E, Chia A, Chen M, Khakpoor A, Pavesi A, Tan AT, Dandri M, Bertoletti A.
Gastroenterology. 2018 Jul; 155(1):180-193.e6. doi: https://doi.org/10.1053/j.gastro.2018.03.027
STUDYING TCR T CELL ANTI-TUMOR ACTIVITY IN A MICROFLUIDIC INTRAHEPATIC TUMOR MODEL
Adriani G, Pavesi A, Kamm RD.
Methods Cell Biol. 2018; 146:199-214. doi: https://doi.org/10.1016/bs.mcb.2018.05.009
CHARACTERIZING THE ROLE OF MONOCYTES IN T CELL CANCER IMMUNOTHERAPY USING A 3D MICROFLUIDIC MODEL
Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC.
Front Immunol. 2018 Mar 6; 9:416. doi: https://doi.org/10.3389/fimmu.2018.00416
2017
A 3D MICROFLUIDIC MODEL FOR PRECLINICAL EVALUATION OF TCR-ENGINEERED T CELLS AGAINST SOLID TUMORS
Pavesi A, Tan AT, Koh S, Chia A, Colombo M, Antonecchia E, Miccolis C, Ceccarello E, Adriani G, Raimondi MT, Kamm RD, Bertoletti A.
JCI Insight. 2017 Jun 15; 2(12). pii: 89762. doi: https://doi.org/10.1172/jci.insight.89762. eCollection 2017 Jun 15.
HUMAN CARDIAC FIBROBLASTS ADAPTIVE RESPONSES TO CONTROLLED COMBINED MECHANICAL STRAIN AND OXYGEN CHANGES IN VITRO
Ugolini GS, Pavesi A, Rasponi M, Fiore GB, Kamm R, Soncini M.
Elife. 2017 Mar 18; 6. pii: e22847. doi: https://doi.org/10.7554/eLife.22847
A 3D NEUROVASCULAR MICROFLUIDIC MODEL CONSISTING OF NEURONS, ASTROCYTES AND CEREBRAL ENDOTHELIAL CELLS AS A BLOOD-BRAIN BARRIER
Adriani G, Ma D, Pavesi A, Kamm RD, Goh EL.
Lab Chip. 2017 Jan 31; 17(3):448-459. doi: https://doi.org/10.1039/c6lc00638h
2016
MICROFLUIDIC MODELS FOR ADOPTIVE CELL-MEDIATED CANCER IMMUNOTHERAPIES
Adriani G, Pavesi A, Tan AT, Bertoletti A, Thiery JP, Kamm RD.
Drug Discov Today. 2016 Sep; 21(9):1472-1478. doi: https://doi.org/10.1016/j.drudis.2016.05.006
ADVANCES IN MICROFLUIDICS IN COMBATING INFECTIOUS DISEASES
Tay A, Pavesi A, Yazdi SR, Lim CT, Warkiani ME.
Biotechnol Adv. 2016 Jul-Aug; 34(4):404-421. doi: https://doi.org/10.1016/j.biotechadv.2016.02.002
ENGINEERING A 3D MICROFLUIDIC CULTURE PLATFORM FOR TUMOR-TREATING FIELD APPLICATION
Pavesi A, Adriani G, Tay A, Warkiani ME, Yeap WH, Wong SC, Kamm RD.
Sci Rep. 2016 May 24; 6:26584. doi: https://doi.org/10.1038/srep26584